Sequence Detail

ID/Version

Q8K4F0 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=CD226 antigen;AltName: Full=Platelet and T-cell activation antigen 1;AltName: CD_antigen=CD226;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 333 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd226	CD226 antigen	42	97	3	16

Sequence references in MGI

J:165704 Iguchi-Manaka A, et al., Accelerated tumor growth in mice deficient in DNAM-1 receptor. J Exp Med. 2008 Dec 22;205(13):2959-64
J:209990 Chan CJ, et al., The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nat Immunol. 2014 May;15(5):431-8
J:229022 Zhang Z, et al., DNAM-1 controls NK cell activation via an ITT-like motif. J Exp Med. 2015 Nov 16;212(12):2165-82
J:322383 Wang H, et al., Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):988-996