Sequence Detail

ID/Version

Q8K4D7 Q3KPE5 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; EC=3.1.4.11;AltName: Full=Phosphoinositide phospholipase C-zeta-1;AltName: Full=Phospholipase C-zeta-1 {ECO:0000250|UniProtKB:Q86YW0}; Short=PLC-zeta-1 {ECO:00

Provider

SWISS-PROT

Sequence

Polypeptide 647 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Plcz1	phospholipase C, zeta 1	50	98	2	10

Sequence references in MGI

J:77754 Saunders CM, et al., PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Development. 2002 Aug;129(15):3533-44
J:88862 Kouchi Z, et al., Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs. J Biol Chem. 2004 Mar 12;279(11):10408-12
J:90375 Larman MG, et al., Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta. J Cell Sci. 2004 May 15;117(Pt 12):2513-21
J:97438 Sone Y, et al., Nuclear translocation of phospholipase C-zeta, an egg-activating factor, during early embryonic development. Biochem Biophys Res Commun. 2005 May 13;330(3):690-694
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:99910 Kouchi Z, et al., The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta. J Biol Chem. 2005 Jun 3;280(22):21015-21
J:117171 Kuroda K, et al., The role of X/Y linker region and N-terminal EF-hand domain in nuclear translocation and Ca2+ oscillation-inducing activities of phospholipase Czeta, a mammalian egg-activating factor. J Biol Chem. 2006 Sep 22;281(38):27794-805
J:126315 Yoshida N, et al., Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development. 2007 Nov;134(21):3941-52
J:257332 Ito M, et al., Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish. Biol Reprod. 2008 Jun;78(6):1081-90