Sequence Detail

ID/Version

Q8K4B0 Q924K9 Q80UI1 Q8K4D4 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Metastasis-associated protein MTA1;

Provider

SWISS-PROT

Sequence

Polypeptide 715 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mta1	metastasis associated 1	84	109	3	31

Sequence references in MGI

J:71485 Simpson A, et al., Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3. Gene. 2001 Jul 25;273(1):29-39
J:109106 Gururaj AE, et al., MTA1, a transcriptional activator of breast cancer amplified sequence 3. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6670-5
J:123470 Manavathi B, et al., Repression of Six3 by a corepressor regulates rhodopsin expression. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13128-33
J:123916 Balasenthil S, et al., Identification of Pax5 as a target of MTA1 in B-cell lymphomas. Cancer Res. 2007 Aug 1;67(15):7132-8
J:153679 Li DQ, et al., E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17493-8
J:161081 Li DQ, et al., Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J Biol Chem. 2010 Mar 26;285(13):10044-52
J:162763 Kumar R, et al., Metastasis-Associated Protein 1 and Its Short Form Variant Stimulates Wnt1 Transcription through Promoting Its Derepression from Six3 Corepressor. Cancer Res. 2010 Aug 15;70(16):6649-58
J:212789 Cong L, et al., SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function. J Biol Chem. 2011 Dec 23;286(51):43793-808
J:212796 Pakala SB, et al., Regulation of NF-kappaB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis. J Biol Chem. 2010 Jul 30;285(31):23590-7
J:213082 Li DQ, et al., Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun. 2013;4:2545
J:213644 Liu J, et al., The subcellular distribution and function of MTA1 in cancer differentiation. Oncotarget. 2014 Jul 15;5(13):5153-64
J:240892 Nitarska J, et al., A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. Cell Rep. 2016 Nov 01;17(6):1683-1698
J:252688 Liu K, et al., TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1. J Cell Sci. 2017 Nov 15;130(22):3809-3817
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319689 Zhang T, et al., A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes. Nat Commun. 2018 Sep 18;9(1):3798
J:319940 Yan L, et al., PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex. Adv Sci (Weinh). 2021 Aug;8(16):e2102060