Sequence Detail

ID/Version

Q8K3Y3 Q6NV62 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Protein lin-28 homolog A; Short=Lin-28A;AltName: Full=Testis-expressed protein 17;

Provider

SWISS-PROT

Sequence

Polypeptide 209 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lin28a	lin-28 homolog A	89	125	4	85

Sequence references in MGI

J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
J:83937 Moss EG, et al., Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites. Dev Biol. 2003 Jun 15;258(2):432-42
J:86961 Yang DH, et al., Temporally regulated expression of Lin-28 in diverse tissues of the developing mouse. Gene Expr Patterns. 2003 Dec;3(6):719-26
J:90573 Sempere LF, et al., Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 2004;5(3):R13
J:121228 Polesskaya A, et al., Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency. Genes Dev. 2007 May 1;21(9):1125-38
J:152654 Rybak A, et al., A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol. 2008 Aug;10(8):987-93
J:152656 Viswanathan SR, et al., Selective blockade of microRNA processing by Lin28. Science. 2008 Apr 4;320(5872):97-100
J:205289 Shyh-Chang N, et al., Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell. 2013 Nov 7;155(4):778-92
J:235236 O'Day E, et al., An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17;290(29):17909-22
J:235254 Cho J, et al., LIN28A is a suppressor of ER-associated translation in embryonic stem cells. Cell. 2012 Nov 9;151(4):765-77
J:262365 Faehnle CR, et al., Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nat Struct Mol Biol. 2017 Aug;24(8):658-665