Sequence Detail

ID/Version

Q8K3K8 A2ASP3 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Optineurin;

Provider

SWISS-PROT

Sequence

Polypeptide 584 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Optn	optineurin	61	108	3	25

Sequence references in MGI

J:95937 Rezaie T, et al., Molecular cloning, genomic structure, and protein characterization of mouse optineurin. Genomics. 2005 Jan;85(1):131-8
J:160709 Chi ZL, et al., Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice. Hum Mol Genet. 2010 Jul 1;19(13):2606-15
J:199188 Minegishi Y, et al., Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma. Hum Mol Genet. 2013 Sep 1;22(17):3559-67
J:247255 Slowicka K, et al., Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-kappaB signaling. Eur J Immunol. 2016 Apr;46(4):971-80
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89