Sequence Detail

ID/Version

Q8K3I6 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interleukin-27 subunit alpha; Short=IL-27 subunit alpha; Short=IL-27-A; Short=IL27-A;AltName: Full=p28;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 234 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il27	interleukin 27	15	97	2	20

Sequence references in MGI

J:77522 Pflanz S, et al., IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4(+) T Cells. Immunity. 2002 Jun;16(6):779-90
J:86979 Lucas S, et al., IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15047-52
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107281 Morishima N, et al., Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27. J Immunol. 2005 Aug 1;175(3):1686-93
J:112649 Stumhofer JS, et al., Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol. 2006 Sep;7(9):937-45
J:112662 Batten M, et al., Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol. 2006 Sep;7(9):929-36
J:123476 Neufert C, et al., IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur J Immunol. 2007 Jul;37(7):1809-16
J:126267 Villarino AV, et al., IL-27 limits IL-2 production during Th1 differentiation. J Immunol. 2006 Jan 1;176(1):237-47
J:129424 Owaki T, et al., IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3. J Immunol. 2006 Mar 1;176(5):2773-80
J:132223 Shimizu M, et al., Antiangiogenic and antitumor activities of IL-27. J Immunol. 2006 Jun 15;176(12):7317-24
J:139438 Yoshimura T, et al., Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J Immunol. 2006 Oct 15;177(8):5377-85
J:140602 Owaki T, et al., IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways. J Immunol. 2006 Dec 1;177(11):7579-87
J:148591 Molle C, et al., IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3. J Immunol. 2007 Jun 15;178(12):7607-15
J:151823 Fitzgerald DC, et al., Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol. 2007 Sep 1;179(5):3268-75