Sequence Detail

ID/Version

Q8K3G9 Q99LT7 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=DCC-interacting protein 13-beta {ECO:0000250|UniProtKB:Q8NEU8}; Short=Dip13-beta {ECO:0000303|Ref.1};AltName: Full=Adapter protein containing PH domain, PTB domain and leucine zipper motif 2 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 662 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Appl2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	72	99	3	8

Sequence references in MGI

J:156351 Wang C, et al., Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. J Biol Chem. 2009 Nov 13;284(46):31608-15
J:226873 Mao L, et al., Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell Biosci. 2014;4(1):60
J:227340 Tan Y, et al., Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts. J Cell Physiol. 2016 May;231(5):1142-50
J:230004 Cheng KK, et al., The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes. 2014 Nov;63(11):3748-58
J:261013 Wang B, et al., Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system. EMBO Rep. 2018 Apr;19(4)
J:268007 Yeo JC, et al., Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages. Traffic. 2016 Sep;17(9):1014-26
J:268015 Yeo JC, et al., Rab31 and APPL2 enhance FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages. Mol Biol Cell. 2015 Mar 1;26(5):952-65
J:268033 Gao C, et al., Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor. Mol Neurobiol. 2018 Jul;55(7):5537-5547
J:268172 Gao C, et al., Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. Mol Neurobiol. 2018 Dec;55(12):9334-9348
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89