Sequence Detail

ID/Version

Q8K2C6 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=NAD-dependent protein deacylase sirtuin-5, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03160}; EC=2.3.1.- {ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:24703693};AltName: Full=Regulatory protein SIR2 homolog 5 {ECO:0000255|HAMAP-

Provider

SWISS-PROT

Sequence

Polypeptide 310 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sirt5	sirtuin 5	56	100	3	16

Sequence references in MGI

J:148769 Nakagawa T, et al., SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 2009 May 1;137(3):560-70
J:177830 Du J, et al., Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011 Nov 11;334(6057):806-9
J:180637 Peng C, et al., The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics. 2011 Dec;10(12):M111.012658
J:191242 Nakamura Y, et al., SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice. FEBS Lett. 2012 Nov 30;586(23):4076-81
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:205149 Yu J, et al., Metabolic characterization of a Sirt5 deficient mouse model. Sci Rep. 2013;3:2806
J:205910 Rardin MJ, et al., SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 2013 Dec 3;18(6):920-33
J:213152 Tan M, et al., Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 2014 Apr 1;19(4):605-17
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89