Sequence Detail

ID/Version

Q8K211 Q3UAJ9 Q8BXJ1 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=High affinity copper uptake protein 1 {ECO:0000305};AltName: Full=Copper transporter 1 {ECO:0000303|PubMed:20699218}; Short=CTR1 {ECO:0000303|PubMed:20699218};AltName: Full=Solute carrier family 31 member 1;Contains: RecName: Full=T

Provider

SWISS-PROT

Sequence

Polypeptide 196 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc31a1	solute carrier family 31, member 1	79	107	3	72

Sequence references in MGI

J:69862 Kuo YM, et al., The copper transporter CTR1 provides an essential function in mammalian embryonic development. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6836-41
J:69897 Lee J, et al., Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6842-7
J:79745 Lee J, et al., Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. J Biol Chem. 2002 Oct 25;277(43):40253-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:129741 Nose Y, et al., Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. Cell Metab. 2006 Sep;4(3):235-44
J:166794 Nose Y, et al., Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. J Biol Chem. 2010 Oct 15;285(42):32385-92
J:202898 Ohrvik H, et al., Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4279-88
J:235011 Ohrvik H, et al., Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain. J Biol Chem. 2016 Jul 1;291(27):13905-16
J:274891 Ghaffari R, et al., Copper transporter 1 (CTR1) expression by mouse testicular germ cells, but not Sertoli cells, is essential for functional spermatogenesis. PLoS One. 2019;14(4):e0215522
J:321043 Das A, et al., Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis. Nat Cell Biol. 2022 Jan;24(1):35-50
J:333129 Bertinato J, et al., Ctr1 transports silver into mammalian cells. J Trace Elem Med Biol. 2010 Jul;24(3):178-84
J:333130 Ishida S, et al., Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14298-302
J:333131 Pabla N, et al., The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. Am J Physiol Renal Physiol. 2009 Mar;296(3):F505-11
J:333181 Holzer AK, et al., Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin. Mol Pharmacol. 2006 Oct;70(4):1390-4