Sequence Detail

ID/Version

Q8K209 Q3UR17 Q9QZT2 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Adhesion G-protein coupled receptor G1 {ECO:0000305};AltName: Full=G-protein coupled receptor 56 {ECO:0000303|PubMed:27068534};AltName: Full=Serpentine receptor cyt28;Contains: RecName: Full=Adhesion G-protein coupled receptor G1, N-termina

Provider

SWISS-PROT

Sequence

Polypeptide 687 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adgrg1	adhesion G protein-coupled receptor G1	86	121	3	12

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:136385 Li S, et al., GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci. 2008 May 28;28(22):5817-26
J:137733 Iguchi T, et al., Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway. J Biol Chem. 2008 May 23;283(21):14469-78
J:149816 Koirala S, et al., GPR56-regulated granule cell adhesion is essential for rostral cerebellar development. J Neurosci. 2009 Jun 10;29(23):7439-49
J:166517 Chen G, et al., GPR56 is essential for testis development and male fertility in mice. Dev Dyn. 2010 Dec;239(12):3358-67
J:176019 Luo R, et al., G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12925-30
J:199497 Saito Y, et al., Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56. Leukemia. 2013 Aug;27(8):1637-49
J:209144 Bae BI, et al., Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14;343(6172):764-8
J:232853 Chiang NY, et al., Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility. J Cell Sci. 2016 Jun 1;129(11):2156-69
J:264148 Giera S, et al., Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. Elife. 2018 May 29;7:e33385
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297533 Yeung J, et al., GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28275-28286
J:309995 Li T, et al., A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding. EMBO J. 2020 Aug 17;39(16):e104136
J:362013 Zhu B, et al., GAIN domain-mediated cleavage is required for activation of G protein-coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist. J Biol Chem. 2019 Dec 13;294(50):19246-19254
J:362022 Lin H, et al., Sensing steroid hormone 17alpha-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury. Cell Metab. 2024 Nov 5;36(11):2402-2418.e10