Sequence Detail

ID/Version

Q8K1R3 Q812B3 Q810U7 Q9DC52 Q8R2U3 Q3UEP9 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Polyribonucleotide nucleotidyltransferase 1, mitochondrial; EC=2.7.7.8;AltName: Full=3'-5' RNA exonuclease OLD35;AltName: Full=PNPase old-35;AltName: Full=Polynucleotide phosphorylase 1; Short=PNPase 1;AltName: Full=Polynucle

Provider

SWISS-PROT

Sequence

Polypeptide 783 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pnpt1	polyribonucleotide nucleotidyltransferase 1	78	98	2	9

Sequence references in MGI

J:84957 Raijmakers R, et al., Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. J Mol Biol. 2002 Nov 1;323(4):653-63
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114639 Chen HW, et al., Mammalian Polynucleotide Phosphorylase Is an Intermembrane Space RNase That Maintains Mitochondrial Homeostasis. Mol Cell Biol. 2006 Nov;26(22):8475-87
J:167932 Wang G, et al., PNPASE regulates RNA import into mitochondria. Cell. 2010 Aug 6;142(3):456-67
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89