Sequence Detail

ID/Version

Q8K1N1 Q8VEC0 Q3TH33 Q9DC20 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Calcium-independent phospholipase A2-gamma {ECO:0000305|PubMed:17923475}; EC=3.1.1.- {ECO:0000269|PubMed:17923475, ECO:0000269|PubMed:28442572}; EC=3.1.1.5 {ECO:0000250|UniProtKB:Q9NP80};AltName: Full=Intracellular membrane-a

Provider

SWISS-PROT

Sequence

Polypeptide 776 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pnpla8	patatin-like phospholipase domain containing 8	42	96	3	12

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120895 Mancuso DJ, et al., Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. J Biol Chem. 2007 Mar 23;282(12):9216-27
J:128989 Mancuso DJ, et al., Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype. J Biol Chem. 2007 Nov 30;282(48):34611-22
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:246027 Liu GY, et al., The phospholipase iPLA2gamma is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling. J Biol Chem. 2017 Jun 23;292(25):10672-10684
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89