Sequence Detail

ID/Version

Q8JZQ2 (UniProt | EBI)

Last sequence update: 2002-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=AFG3-like protein 2 {ECO:0000305}; EC=3.4.24.- {ECO:0000250|UniProtKB:Q9Y4W6};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 802 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Afg3l2	AFG3-like AAA ATPase 2	42	98	3	12

Sequence references in MGI

J:117691 Koppen M, et al., Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia. Mol Cell Biol. 2007 Jan;27(2):758-67
J:132285 Maltecca F, et al., The mitochondrial protease AFG3L2 is essential for axonal development. J Neurosci. 2008 Mar 12;28(11):2827-36
J:164484 Koppen M, et al., Autocatalytic processing of m-AAA protease subunits in mitochondria. Mol Biol Cell. 2009 Oct;20(19):4216-24
J:187268 Mancuso G, et al., Alternative splicing of Spg7, a gene involved in hereditary spastic paraplegia, encodes a variant of paraplegin targeted to the endoplasmic reticulum. PLoS One. 2012;7(5):e36337
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:215238 Richter-Dennerlein R, et al., DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. Cell Metab. 2014 Jul 1;20(1):158-71
J:248860 Konig T, et al., The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria. Mol Cell. 2016 Oct 6;64(1):148-162
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89