Sequence Detail

ID/Version

Q8CIW5 Q8K1Z1 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Twinkle mtDNA helicase {ECO:0000312|MGI:MGI:2137410}; EC=5.6.2.3 {ECO:0000250|UniProtKB:Q96RR1};AltName: Full=Progressive external ophthalmoplegia 1 protein homolog;AltName: Full=T7 gp4-like protein with intramitochondrial nucleoid l

Provider

SWISS-PROT

Sequence

Polypeptide 685 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Twnk	twinkle mtDNA helicase	55	96	3	16

Sequence references in MGI

J:95313 Tyynismaa H, et al., Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number. Hum Mol Genet. 2004 Dec 15;13(24):3219-27
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563