Sequence Detail

ID/Version

Q8CI15 O88886 Q91ZN3 Q3U2E3 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sphingosine kinase 1 {ECO:0000305}; Short=SK 1 {ECO:0000303|PubMed:27806293}; Short=SPK 1; EC=2.7.1.91 {ECO:0000269|PubMed:17346996, ECO:0000269|PubMed:25417698, ECO:0000269|PubMed:33334894};AltName: Full=Acetyltransf

Provider

SWISS-PROT

Sequence

Polypeptide 382 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sphk1	sphingosine kinase 1	161	101	2	13

Sequence references in MGI

J:49744 Kohama T, et al., Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem. 1998 Sep 11;273(37):23722-8
J:95168 Allende ML, et al., Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem. 2004 Dec 10;279(50):52487-92
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103755 Mizugishi K, et al., Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005 Dec;25(24):11113-21
J:120074 Olivera A, et al., The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity. 2007 Mar;26(3):287-97
J:219391 Shen H, et al., Coupling between endocytosis and sphingosine kinase 1 recruitment. Nat Cell Biol. 2014 Jul;16(7):652-62
J:240895 Young MM, et al., Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking. Cell Rep. 2016 Nov 01;17(6):1532-1545
J:261928 Lee JY, et al., Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Nat Commun. 2018 Apr 16;9(1):1479
J:271700 Hisano Y, et al., The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J Biol Chem. 2011 Jan 21;286(3):1758-66
J:273514 Maceyka M, et al., SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem. 2005 Nov 4;280(44):37118-29
J:273518 Lima S, et al., Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. J Biol Chem. 2017 Feb 24;292(8):3074-3088
J:281260 Lee H, et al., Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons. Nat Commun. 2014 Nov 24;5:5514
J:304931 Nguyen TQ, et al., Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b. J Biol Chem. 2020 Dec 17;