Sequence Detail

ID/Version

Q8CHK4 A0A494B9U8 Q8CGZ3 Q3YFI9 Q8CGZ4 Q8VIH0 A1L394 (UniProt | EBI)

Last sequence update: 2003-11-28
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Histone acetyltransferase KAT5 {ECO:0000305}; EC=2.3.1.48 {ECO:0000305|PubMed:32542325};AltName: Full=60 kDa Tat-interactive protein {ECO:0000303|PubMed:12036595}; Short=Tip60 {ECO:0000303|PubMed:12036595};AltName: Full=Histo

Provider

SWISS-PROT

Sequence

Polypeptide 513 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kat5	K(lysine) acetyltransferase 5	149	113	4	19

Sequence references in MGI

J:77074 McAllister D, et al., Characterization and expression of the mouse tat interactive protein 60 kD (TIP60) gene. Gene. 2002 May 1;289(1-2):169-76
J:83989 Legube G, et al., Identification of a larger form of the histone acetyl transferase Tip60. Gene. 2003 May 22;310:161-8
J:113460 Kim MS, et al., Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor. J Biol Chem. 2006 Jun 2;281(22):15082-9
J:125164 Gorrini C, et al., Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature. 2007 Aug 30;448(7157):1063-7
J:151916 Pan F, et al., Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science. 2009 Aug 28;325(5944):1142-6
J:183987 Lin SY, et al., GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science. 2012 Apr 27;336(6080):477-81
J:211791 Xiao Y, et al., Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. Cell Rep. 2014 Jun 12;7(5):1471-80
J:244731 Dong Y, et al., EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice. Mol Cell Biol. 2017 Oct 01;37(19)
J:262920 Li TY, et al., Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018 May 15;9(1):1916
J:277685 Petkau N, et al., Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Elife. 2019 Jul 11;8:e43235
J:278470 Acharya D, et al., TIP55, a splice isoform of the KAT5 acetyltransferase, is essential for developmental gene regulation and organogenesis. Sci Rep. 2018 Oct 8;8(1):14908
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:293083 Li ML, et al., Phosphorylation of TIP60 Suppresses 53BP1 Localization at DNA Damage Sites. Mol Cell Biol. 2019 Jan 1;39(1)
J:295963 Song ZM, et al., KAT5 acetylates cGAS to promote innate immune response to DNA virus. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21568-21575
J:304368 Numata A, et al., Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. Blood. 2020 Oct 8;136(15):1735-1747
J:319695 Jang SM, et al., KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation. Cell Death Dis. 2015 Aug 20;6:e1857
J:319944 Garcia-Gonzalez R, et al., VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage. Cancers (Basel). 2020 Oct 15;12(10):2986