Sequence Detail

ID/Version

Q8CGS6 Q3UTE0 (UniProt | EBI)

Last sequence update: 2015-04-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=DNA polymerase theta {ECO:0000305};AltName: Full=Chromosome aberrations occurring spontaneously protein 1 {ECO:0000303|PubMed:12663541, ECO:0000303|PubMed:15542845};AltName: Full=DNA polymerase eta;Includes: RecName: Full=Helicase POLQ {ECO

Provider

SWISS-PROT

Sequence

Polypeptide 2544 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Polq	polymerase (DNA directed), theta	54	98	3	10

Sequence references in MGI

J:82700 Shima N, et al., Phenotype-based identification of mouse chromosome instability mutants. Genetics. 2003 Mar;163(3):1031-40
J:94088 Shima N, et al., The Mouse Genomic Instability Mutation chaos1 Is an Allele of Polq That Exhibits Genetic Interaction with Atm. Mol Cell Biol. 2004 Dec;24(23):10381-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101409 Masuda K, et al., DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13986-91
J:103365 Zan H, et al., The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation. EMBO J. 2005 Nov 2;24(21):3757-69
J:115989 Masuda K, et al., Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes. DNA Repair (Amst). 2006 Nov 8;5(11):1384-91
J:122996 Masuda K, et al., DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J Biol Chem. 2007 Jun 15;282(24):17387-94
J:138141 Martomo SA, et al., Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes. DNA Repair (Amst). 2008 Sep 1;7(9):1603-8
J:189375 Li Y, et al., Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and gamma-irradiation in mouse B cells. Genes Cells. 2011 Sep;16(9):973-83
J:219558 Mateos-Gomez PA, et al., Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination. Nature. 2015 Feb 12;518(7538):254-7
J:219787 Ceccaldi R, et al., Homologous-recombination-deficient tumours are dependent on Poltheta-mediated repair. Nature. 2015 Feb 12;518(7538):258-62
J:243811 Yousefzadeh MJ, et al., Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet. 2014 Oct;10(10):e1004654
J:249698 Zelensky AN, et al., Inactivation of Pol theta and C-NHEJ eliminates off-target integration of exogenous DNA. Nat Commun. 2017 Jul 07;8(1):66
J:258323 Schimmel J, et al., Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells. EMBO J. 2017 Dec 15;36(24):3634-3649
J:340661 Mateos-Gomez PA, et al., The helicase domain of Poltheta counteracts RPA to promote alt-NHEJ. Nat Struct Mol Biol. 2017 Dec;24(12):1116-1123