Sequence Detail

ID/Version

Q8CFZ4 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Glypican-3;Contains: RecName: Full=Glypican-3 alpha subunit {ECO:0000250|UniProtKB:P51654};Contains: RecName: Full=Glypican-3 beta subunit {ECO:0000250|UniProtKB:P51654};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 579 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gpc3	glypican 3	76	126	3	40

Sequence references in MGI

J:64330 Paine-Saunders S, et al., glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol. 2000 Sep 1;225(1):179-87
J:67732 Grisaru S, et al., Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis. Dev Biol. 2001 Mar 1;231(1):31-46
J:73877 Cano-Gauci DF, et al., Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol. 1999 Jul 12;146(1):255-64
J:96157 Song HH, et al., The loss of glypican-3 induces alterations in Wnt signaling. J Biol Chem. 2005 Jan 21;280(3):2116-25
J:135168 Capurro MI, et al., Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell. 2008 May;14(5):700-11
J:154375 Ng A, et al., Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Dev Biol. 2009 Nov 1;335(1):208-15
J:197437 Bhave VS, et al., Regulation of liver growth by glypican 3, CD81, hedgehog, and hhex. Am J Pathol. 2013 Jul;183(1):153-9