Sequence Detail

ID/Version

Q8CFX1 Q8BLH1 B2KGW7 A2A7A9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=GDH/6PGL endoplasmic bifunctional protein {ECO:0000305|PubMed:12831846};Includes: RecName: Full=Hexose-6-phosphate dehydrogenase {ECO:0000303|PubMed:4169027}; AltName: Full=Glucose 1-dehydrogenase {ECO:0000305|PubMed:4169027}; EC

Provider

SWISS-PROT

Sequence

Polypeptide 789 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	59	101	3	20

Sequence references in MGI

J:84549 Clarke JL, et al., Murine hexose-6-phosphate dehydrogenase: a bifunctional enzyme with broad substrate specificity and 6-phosphogluconolactonase activity. Arch Biochem Biophys. 2003 Jul 15;415(2):229-34
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108281 Lavery GG, et al., Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem. 2006 Mar 10;281(10):6546-51
J:129887 Rogoff D, et al., Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase. Endocrinology. 2007 Oct;148(10):5072-80
J:135336 Lavery GG, et al., Deletion of hexose-6-phosphate dehydrogenase activates the unfolded protein response pathway and induces skeletal myopathy. J Biol Chem. 2008 Mar 28;283(13):8453-61
J:145385 Bujalska IJ, et al., Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue. Endocrinology. 2008 May;149(5):2584-91
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89