Sequence Detail

ID/Version

Q8CFW1 C4N788 Q8C8N6 (UniProt | EBI)

Last sequence update: 2009-11-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Anoctamin-2 {ECO:0000250|UniProtKB:Q9NQ90};AltName: Full=Transmembrane protein 16B {ECO:0000312|EMBL:AAH33409.1};

Provider

SWISS-PROT

Sequence

Polypeptide 1002 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ano2	anoctamin 2	37	98	3	9

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:138798 Rock JR, et al., Expression of TMEM16 paralogs during murine embryogenesis. Dev Dyn. 2008 Sep;237(9):2566-74
J:149521 Stohr H, et al., TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci. 2009 May 27;29(21):6809-18
J:155179 Stephan AB, et al., ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11776-81
J:155364 Pifferi S, et al., TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflugers Arch. 2009 Oct;458(6):1023-38
J:165954 Schreiber R, et al., Expression and function of epithelial anoctamins. J Biol Chem. 2010 Mar 5;285(10):7838-45
J:190271 Duran C, et al., ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C482-93
J:196141 Tien J, et al., Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6352-7