Sequence Detail

ID/Version

Q8CFN5 Q8R0H1 Q9QW20 Q9D7L0 (UniProt | EBI)

Last sequence update: 2005-01-04
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Myocyte-specific enhancer factor 2C {ECO:0000305};AltName: Full=Myocyte enhancer factor 2C {ECO:0000312|MGI:MGI:99458};

Provider

SWISS-PROT

Sequence

Polypeptide 474 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mef2c	myocyte enhancer factor 2C	226	187	4	18

Sequence references in MGI

J:17643 Martin JF, et al., Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5282-6
J:37685 Lin X, et al., The expression of MEF2 genes is implicated in CNS neuronal differentiation. Brain Res Mol Brain Res. 1996 Dec;42(2):307-16
J:40724 Lin Q, et al., Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 1997 May 30;276(5317):1404-7
J:50309 Lin Q, et al., Requirement of the MADS-box transcription factor MEF2C for vascular development. Development. 1998 Nov;125(22):4565-74
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111229 Creemers EE, et al., Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol Cell. 2006 Jul 7;23(1):83-96
J:136292 Wilker PR, et al., Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol. 2008 Jun;9(6):603-12
J:138188 Barbosa AC, et al., MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9391-6
J:138189 Li H, et al., Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9397-402
J:148288 Gekas C, et al., Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 2009 Apr 9;113(15):3461-71
J:159054 Liu GH, et al., Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. PLoS One. 2009;4(9):e7031
J:172163 Angelelli C, et al., Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells. Nucleic Acids Res. 2008 Feb;36(3):915-28
J:175110 Hosking BM, et al., SOX18 directly interacts with MEF2C in endothelial cells. Biochem Biophys Res Commun. 2001 Sep 21;287(2):493-500
J:181087 Mayers CM, et al., The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice. J Biol Chem. 2010 Apr 16;285(16):12344-54
J:283181 Guo A, et al., E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018 Dec 21;362(6421)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89