Sequence Detail

ID/Version

Q8CDG1 Q99MV6 Q3TQE8 A6H617 Q9JMB6 (UniProt | EBI)

Last sequence update: 2006-05-16
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Piwi-like protein 2 {ECO:0000305}; EC=3.1.26.- {ECO:0000269|PubMed:22020280, ECO:0000269|PubMed:23706823, ECO:0000269|PubMed:26669262};

Provider

SWISS-PROT

Sequence

Polypeptide 971 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Piwil2	piwi-like RNA-mediated gene silencing 2	53	124	3	12

Sequence references in MGI

J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
J:71909 Kuramochi-Miyagawa S, et al., Two mouse piwi-related genes: miwi and mili. Mech Dev. 2001 Oct;108(1-2):121-33
J:87735 Kuramochi-Miyagawa S, et al., Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development. 2004 Feb;131(4):839-49
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104922 Lee JH, et al., Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes. Mol Reprod Dev. 2006 Feb;73(2):173-9
J:112036 Costa Y, et al., Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006 Aug 1;15(15):2324-34
J:121322 Aravin AA, et al., Developmentally regulated piRNA clusters implicate MILI in transposon control. Science. 2007 May 4;316(5825):744-7
J:133343 Kuramochi-Miyagawa S, et al., DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 2008 Apr 1;22(7):908-17
J:135163 Watanabe T, et al., Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature. 2008 May 22;453(7194):539-43
J:141096 Aravin AA, et al., A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell. 2008 Sep 26;31(6):785-99
J:147897 Unhavaithaya Y, et al., MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem. 2009 Mar 6;284(10):6507-19
J:148065 Aravin A, et al., A novel class of small RNAs bind to MILI protein in mouse testes. Nature. 2006 Jul 13;442(7099):203-7
J:148941 Wang J, et al., Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis. Curr Biol. 2009 Apr 28;19(8):640-4
J:151086 Vagin VV, et al., Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 2009 Aug 1;23(15):1749-62
J:152108 Reuter M, et al., Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat Struct Mol Biol. 2009 Jun;16(6):639-46
J:155574 Chen C, et al., Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20336-41
J:159518 Kuramochi-Miyagawa S, et al., MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev. 2010 May;24(9):887-92
J:161124 Frost RJ, et al., MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11847-52
J:161125 Zheng K, et al., Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11841-6
J:184034 De Fazio S, et al., The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature. 2011 Dec 8;480(7376):259-63
J:199259 Di Giacomo M, et al., Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis. Mol Cell. 2013 May 23;50(4):601-8
J:202012 Pandey RR, et al., Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7
J:229314 Yang Z, et al., PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Mol Cell. 2016 Jan 7;61(1):138-52
J:239197 Shiromoto Y, et al., GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. RNA. 2013 Jun;19(6):803-10
J:243444 Tarabay Y, et al., Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression. J Cell Sci. 2017 Apr 15;130(8):1463-1474
J:243488 Wenda JM, et al., Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function. Dev Cell. 2017 Jun 19;41(6):623-637.e9
J:272534 Lu Y, et al., Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. Oncotarget. 2017 Aug 15;8(33):54913-54924
J:288732 Yang F, et al., TEX15 associates with MILI and silences transposable elements in male germ cells. Genes Dev. 2020 Jun 1;34(11-12):745-750
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89