Sequence Detail

ID/Version

Q8CDA1 Q6NX83 Q8C8G7 Q3UCS0 Q8CBW2 Q6ZQ16 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Phosphatidylinositide phosphatase SAC2; EC=3.1.3.25 {ECO:0000250|UniProtKB:Q9Y2H2, ECO:0000269|PubMed:25869669};AltName: Full=Inositol polyphosphate 5-phosphatase F {ECO:0000312|MGI:MGI:2141867};AltName: Full=Sac domain-containing in

Provider

SWISS-PROT

Sequence

Polypeptide 1132 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Inpp5f	inositol polyphosphate-5-phosphatase F	65	108	3	3

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:121697 Trivedi CM, et al., Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31
J:170072 Zhu W, et al., Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Circ Res. 2009 Dec 4;105(12):1240-7
J:225812 Zou Y, et al., Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. J Neurosci. 2015 Jul 22;35(29):10429-39
J:229329 Hsu F, et al., Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling. J Cell Biol. 2015 Apr 13;209(1):97-110
J:230616 Nakatsu F, et al., Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. J Cell Biol. 2015 Apr 13;209(1):85-95
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89