Sequence Detail

ID/Version

Q8CD54 Q9D341 Q8BSM4 E2JF23 (UniProt | EBI)

Last sequence update: 2011-01-11
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Piezo-type mechanosensitive ion channel component 2;AltName: Full=Protein FAM38B {ECO:0000303|PubMed:20813920};

Provider

SWISS-PROT

Sequence

Polypeptide 2822 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Piezo2	piezo-type mechanosensitive ion channel component 2	30	100	2	17

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:164433 Coste B, et al., Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science. 2010 Oct 1;330(6000):55-60
J:211312 Woo SH, et al., Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014 May 29;509(7502):622-6
J:213170 Poole K, et al., Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch. Nat Commun. 2014;5:3520
J:217527 Ranade SS, et al., Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature. 2014 Dec 4;516(7529):121-5
J:243620 Nonomura K, et al., Piezo2 senses airway stretch and mediates lung inflation-induced apnoea. Nature. 2017 Jan 12;541(7636):176-181
J:245270 Coste B, et al., Piezo proteins are pore-forming subunits of mechanically activated channels. Nature. 2012 Feb 19;483(7388):176-81
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:299967 Marshall KL, et al., PIEZO2 in sensory neurons and urothelial cells coordinates urination. Nature. 2020 Dec;588(7837):290-295
J:339334 Woo SH, et al., Piezo2 is the principal mechanotransduction channel for proprioception. Nat Neurosci. 2015 Dec;18(12):1756-62
J:344999 Wang L, et al., Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature. 2019 Sep;573(7773):225-229
J:349395 Lee JH, et al., The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell. Nat Commun. 2024 Jan 16;15(1):526
J:349398 Zhang X, et al., TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction. Cell Rep. 2024 Apr 23;43(4):114014
J:363380 Passini FS, et al., Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism. Cell Metab. 2025 Jan 29;