Sequence Detail

ID/Version

Q8CCJ3 Q6ZQ50 Q9D8I8 Q8BT70 B1AXU6 B1AXU5 A2RSP7 Q3V145 Q8C484 (UniProt | EBI)

Last sequence update: 2005-06-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 UFM1-protein ligase 1 {ECO:0000305}; EC=2.3.2.- {ECO:0000250|UniProtKB:O94874};AltName: Full=E3 UFM1-protein transferase 1 {ECO:0000305};AltName: Full=Multiple alpha-helix protein located at ER {ECO:0000303|PubMed:20531390};AltNam

Provider

SWISS-PROT

Sequence

Polypeptide 793 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ufl1	UFM1 specific ligase 1	109	102	3	6

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:162095 Shiwaku H, et al., Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J. 2010 Jul 21;29(14):2446-60
J:163051 Wu J, et al., A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem. 2010 May 14;285(20):15126-36
J:217277 Lemaire K, et al., Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. PLoS One. 2011;6(4):e18517
J:238253 Zhang M, et al., RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis. Cell Death Differ. 2015 Dec;22(12):1922-34
J:272566 Yang R, et al., CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development. 2019 Jan 25;146(2):dev169235
J:277769 Simsek D, et al., The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Cell. 2017 Jun 1;169(6):1051-1065.e18
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298771 Cai Y, et al., Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. Cell Discov. 2019;5:7
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:319822 Li J, et al., Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure. Circ Heart Fail. 2018 Oct;11(10):e004917
J:347148 Luo H, et al., UFMylation of HRD1 regulates endoplasmic reticulum homeostasis. FASEB J. 2023 Nov;37(11):e23221
J:347152 He C, et al., UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity. Mol Cell. 2024 Mar 21;84(6):1120-1138.e8