Sequence Detail

ID/Version

Q8CBR6 Q4W655 (UniProt | EBI)

Last sequence update: 2006-06-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tsukushi {ECO:0000303|PubMed:21856951};AltName: Full=Leucine-rich repeat-containing protein 54 {ECO:0000312|MGI:MGI:2443855};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 354 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tsku	tsukushi, small leucine rich proteoglycan	11	102	3	12

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:166597 Ito A, et al., Tsukushi is required for anterior commissure formation in mouse brain. Biochem Biophys Res Commun. 2010 Nov 26;402(4):813-8
J:175224 Ohta K, et al., Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14962-7
J:190629 Niimori D, et al., Tsukushi controls the hair cycle by regulating TGF-beta1 signaling. Dev Biol. 2012 Dec 1;372(1):81-7
J:193105 Hossain M, et al., The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation. Dev Biol. 2013 Feb 1;374(1):58-70
J:284921 Wang Q, et al., The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation. Nat Metab. 2019 Feb;1(2):251-260
J:286890 Mouchiroud M, et al., The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis. JCI Insight. 2019 Aug 8;4(15)
J:288268 Miwa T, et al., Tsukushi is essential for the development of the inner ear. Mol Brain. 2020 Mar 3;13(1):29
J:297320 Niimori D, et al., Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors. J Cell Commun Signal. 2014 Sep;8(3):173-7
J:297327 Ohta K, et al., CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi. J Cell Commun Signal. 2019 Mar;13(1):113-118
J:297329 Mouchiroud M, et al., The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis. Mol Metab. 2019 Dec;30:184-191
J:297528 Ahmad SAI, et al., Tsukushi is essential for proper maintenance and terminal differentiation of mouse hippocampal neural stem cells. Dev Growth Differ. 2020 Feb;62(2):108-117
J:319829 Xiong X, et al., Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi. Mol Metab. 2019 Feb;20:128-137