Sequence Detail

ID/Version

Q8C6L5 Q3ULW3 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Cyclic GMP-AMP synthase {ECO:0000303|PubMed:23258413}; Short=cGAMP synthase {ECO:0000303|PubMed:23258413}; Short=cGAS {ECO:0000303|PubMed:23258413}; Short=m-cGAS {ECO:0000303|PubMed:23258413}; EC=2.7.7.86 {ECO

Provider

SWISS-PROT

Sequence

Polypeptide 507 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cgas	cyclic GMP-AMP synthase	150	97	3	25

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:196208 Sun L, et al., Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91
J:198729 Ablasser A, et al., cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013 Jun 20;498(7454):380-4
J:199863 Gao D, et al., Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science. 2013 Aug 23;341(6148):903-6
J:209295 Li X, et al., Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity. 2013 Dec 12;39(6):1019-31
J:231311 Xia P, et al., Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016 Apr;17(4):369-78
J:241001 Tao J, et al., Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation. J Immunol. 2017 May 01;198(9):3627-3636
J:241014 Lee A, et al., The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity. FEBS Lett. 2017 Mar;591(6):954-961
J:243386 Ablasser A, et al., Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4
J:243563 Gluck S, et al., Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence. Nat Cell Biol. 2017 Sep;19(9):1061-1070
J:243901 Wang Y, et al., Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection. Immunity. 2017 Mar 21;46(3):393-404
J:246297 Cui Y, et al., SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing. PLoS Pathog. 2017 Jan;13(1):e1006156
J:250116 Mackenzie KJ, et al., cGAS surveillance of micronuclei links genome instability to innate immunity. Nature. 2017 Aug 24;548(7668):461-465
J:257953 Seo GJ, et al., TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing. Nat Commun. 2018 Feb 9;9(1):613
J:259271 Hu MM, et al., Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus. Immunity. 2016 Sep 20;45(3):555-569
J:263151 Bridgeman A, et al., Viruses transfer the antiviral second messenger cGAMP between cells. Science. 2015 Sep 11;349(6253):1228-32
J:267189 Liu H, et al., Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature. 2018 Nov;563(7729):131-136
J:268008 Zhou W, et al., Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 Jul 12;174(2):300-311.e11
J:273551 Barnett KC, et al., Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. 2019 Mar 7;176(6):1432-1446.e11
J:274136 Ning X, et al., Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3. Mol Cell. 2019 Apr 4;74(1):19-31.e7
J:280913 Jiang H, et al., Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. EMBO J. 2019 Oct 4;38(21):e102718
J:281254 Vincent J, et al., Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750
J:300652 Volkman HE, et al., Tight nuclear tethering of cGAS is essential for preventing autoreactivity. Elife. 2019 Dec 6;8:e47491
J:305320 Xia P, et al., A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Immunity. 2018 Apr 17;48(4):688-701.e7
J:310174 Zhang Q, et al., USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity. Cell Res. 2020 Oct;30(10):914-927
J:313955 Zhao B, et al., The molecular basis of tight nuclear tethering and inactivation of cGAS. Nature. 2020 Nov;587(7835):673-677
J:314373 Michalski S, et al., Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature. 2020 Nov;587(7835):678-682
J:314393 Li M, et al., Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response. Protein Cell. 2020 Aug;11(8):584-599
J:314911 Boyer JA, et al., Structural basis of nucleosome-dependent cGAS inhibition. Science. 2020 Oct 23;370(6515):450-454
J:325965 Wang F, et al., Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. Mol Cell. 2022 Jun 2;82(11):2032-2049.e7
J:326061 Xiao Y, et al., RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair. Bone Res. 2022 Feb 24;10(1):19
J:349030 Cho MG, et al., MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis. Nature. 2024 Jan;625(7995):585-592
J:355682 Li H, et al., AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases. Nature. 2024 Sep 25;
J:367051 Andreeva L, et al., cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature. 2017 Sep 21;549(7672):394-398