Sequence Detail

ID/Version

Q8C669 Q91YL9 Q9ERJ8 Q9CV22 (UniProt | EBI)

Last sequence update: 2003-10-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase pellino homolog 1; Short=Pellino-1; EC=2.3.2.27;AltName: Full=RING-type E3 ubiquitin transferase pellino homolog 1 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 418 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Peli1	pellino 1	59	101	4	25

Sequence references in MGI

J:68867 Resch K, et al., Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. Cytogenet Cell Genet. 2001;92(1-2):172-4
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:263339 Choi SW, et al., PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Mol Cell. 2018 Jun 7;70(5):920-935.e7
J:279762 Dai D, et al., Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation. Sci Rep. 2019 May 29;9(1):8034
J:302301 Ko CJ, et al., The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses. EMBO J. 2021 Jan 15;40(2):e104532
J:321781 Zhang L, et al., Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination. Cell Rep. 2021 Oct 26;37(4):109904