Sequence Detail

ID/Version

Q8C3P7 Q9WUI4 Q9CV54 Q9ERS9 (UniProt | EBI)

Last sequence update: 2003-07-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=N(6)-adenosine-methyltransferase catalytic subunit METTL3; EC=2.1.1.348 {ECO:0000269|PubMed:24394384};AltName: Full=Methyltransferase-like protein 3;AltName: Full=N(6)-adenosine-methyltransferase 70 kDa subunit; Short=MT-A70;

Provider

SWISS-PROT

Sequence

Polypeptide 580 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mettl3	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	94	110	3	41

Sequence references in MGI

J:69146 Hwang SY, et al., Expression of genes involved in mammalian meiosis during the transition from egg to embryo. Mol Reprod Dev. 2001 Jun;59(2):144-58
J:70548 Bokar JA, et al., Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA. 1997 Nov;3(11):1233-47
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:203416 Fustin JM, et al., RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806
J:207885 Wang Y, et al., N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat Cell Biol. 2014 Feb;16(2):191-8
J:219587 Geula S, et al., Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science. 2015 Feb 27;347(6225):1002-6
J:219614 Batista PJ, et al., m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19
J:247703 Yoon KJ, et al., Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation. Cell. 2017 Nov 02;171(4):877-889.e17
J:248553 Ke S, et al., m(6)A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover. Genes Dev. 2017 May 15;31(10):990-1006
J:249262 Li HB, et al., m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature. 2017 Aug 17;548(7667):338-342
J:250428 Lin Z, et al., Mettl3-/Mettl14-mediated mRNA N(6)-methyladenosine modulates murine spermatogenesis. Cell Res. 2017 Oct;27(10):1216-1230
J:250433 Xu K, et al., Mettl3-mediated m(6)A regulates spermatogonial differentiation and meiosis initiation. Cell Res. 2017 Sep;27(9):1100-1114
J:261823 Wen J, et al., Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal. Mol Cell. 2018 Mar 15;69(6):1028-1038.e6
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:299108 Lasman L, et al., Context-dependent functional compensation between Ythdf m(6)A reader proteins. Genes Dev. 2020 Oct 1;34(19-20):1373-1391
J:345540 Knuckles P, et al., Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d. Genes Dev. 2018 Mar 1;32(5-6):415-429