Sequence Detail

ID/Version

Q8C172 Q8BV12 Q3U817 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ceramide synthase 6 {ECO:0000305}; Short=CerS6 {ECO:0000305}; EC=2.3.1.- {ECO:0000269|PubMed:15823095, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:31150623};AltName: Full=LAG1 longevity assurance homolog 6 {ECO:0000303|Pu

Provider

SWISS-PROT

Sequence

Polypeptide 384 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cers6	ceramide synthase 6	25	101	3	30

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117553 Mizutani Y, et al., Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005 Aug 15;390(Pt 1):263-71
J:188736 Schiffmann S, et al., Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis. J Immunol. 2012 Jun 1;188(11):5723-33
J:201327 Ebel P, et al., Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities. J Biol Chem. 2013 Jul 19;288(29):21433-47
J:215519 Turpin SM, et al., Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 2014 Oct 7;20(4):678-86
J:230048 Novgorodov SA, et al., SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22;291(4):1957-73
J:286914 Hammerschmidt P, et al., CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell. 2019 May 30;177(6):1536-1552.e23