Sequence Detail

ID/Version

Q8C0T0 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=XK-related protein 8 {ECO:0000305}; Short=mXkr8 {ECO:0000303|PubMed:23845944};Contains: RecName: Full=XK-related protein 8, processed form {ECO:0000250|UniProtKB:Q9H6D3};

Provider

SWISS-PROT

Sequence

Polypeptide 401 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Xkr8	X-linked Kx blood group related 8	34	96	6	10

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:199440 Suzuki J, et al., Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science. 2013 Jul 26;341(6144):403-6
J:235607 Suzuki J, et al., Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9509-14
J:265778 Kawano M, et al., Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2132-2137
J:273974 Kautzman AG, et al., Xkr8 Modulates Bipolar Cell Number in the Mouse Retina. Front Neurosci. 2018;12:876
J:293092 Yamashita Y, et al., Infertility Caused by Inefficient Apoptotic Germ Cell Clearance in Xkr8-Deficient Male Mice. Mol Cell Biol. 2020 Jan 16;40(3)
J:306586 Suzuki J, et al., Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. J Biol Chem. 2014 Oct 31;289(44):30257-30267
J:306596 Sakuragi T, et al., Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2907-2912
J:317385 Kim GW, et al., Xk-related protein 8 regulates myoblast differentiation and survival. FEBS J. 2017 Nov;284(21):3575-3588