Sequence Detail

ID/Version

Q8BZA9 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Fructose-2,6-bisphosphatase TIGAR {ECO:0000305}; EC=3.1.3.46 {ECO:0000250|UniProtKB:Q9NQ88};AltName: Full=TP53-induced glycolysis and apoptosis regulator {ECO:0000250|UniProtKB:Q9NQ88};AltName: Full=TP53-induced glycolysis regulatory

Provider

SWISS-PROT

Sequence

Polypeptide 269 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tigar	Trp53 induced glycolysis regulatory phosphatase	72	104	4	86

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:167245 Kimata M, et al., p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1908-16
J:183674 Hoshino A, et al., p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol. 2012 Jan;52(1):175-84
J:198650 Cheung EC, et al., TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis. Dev Cell. 2013 Jun 10;25(5):463-77
J:211335 Li M, et al., A TIGAR-regulated metabolic pathway is critical for protection of brain ischemia. J Neurosci. 2014 May 28;34(22):7458-71
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89