Sequence Detail

ID/Version

Q8BXR5 Q8BYM2 (UniProt | EBI)

Last sequence update: 2008-01-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sodium leak channel NALCN {ECO:0000305};AltName: Full=Sodium leak channel non-selective protein;AltName: Full=Voltage gated channel-like protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 1738 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nalcn	sodium leak channel, non-selective	28	98	3	11

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:141581 Lu B, et al., The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell. 2007 Apr 20;129(2):371-83
J:145000 Lu B, et al., Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature. 2009 Feb 5;457(7230):741-4
J:167858 Lu B, et al., Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron. 2010 Nov 4;68(3):488-99
J:171768 Sinke AP, et al., Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics. 2011 Mar 16;43(5):265-70
J:233576 Swayne LA, et al., The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line. EMBO Rep. 2009 Aug;10(8):873-80
J:234021 Lutas A, et al., The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons. Elife. 2016;5:e15271