Sequence Detail

ID/Version

Q8BWC0 Q8BTJ7 Q6NSV0 Q8R396 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Two pore channel protein 2;AltName: Full=Two pore calcium channel protein 2 {ECO:0000305};AltName: Full=Voltage-dependent calcium channel protein TPC2;

Provider

SWISS-PROT

Sequence

Polypeptide 731 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tpcn2	two pore segment channel 2	89	102	3	12

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:149472 Calcraft PJ, et al., NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature. 2009 May 28;459(7246):596-600
J:165894 Tugba Durlu-Kandilci N, et al., TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle. J Biol Chem. 2010 Aug 6;285(32):24925-32
J:175340 Schieder M, et al., Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes. J Biol Chem. 2010 Jul 9;285(28):21219-22
J:175352 Zong X, et al., The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores. Pflugers Arch. 2009 Sep;458(5):891-9
J:189070 Wang X, et al., TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes. Cell. 2012 Oct 12;151(2):372-83
J:193600 Cang C, et al., mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na(+) Channels to Adapt to Metabolic State. Cell. 2013 Feb 14;152(4):778-90
J:225206 Grimm C, et al., High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nat Commun. 2014;5:4699
J:306587 Sakurai Y, et al., Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. Science. 2015 Feb 27;347(6225):995-8
J:306599 Gerndt S, et al., Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife. 2020 Mar 16;9:e54712
J:328828 Bellono NW, et al., A melanosomal two-pore sodium channel regulates pigmentation. Sci Rep. 2016 May 27;6:26570