Sequence Detail

ID/Version

Q8BVZ5 Q3TQN0 Q99L46 Q2YEJ4 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interleukin-33; Short=IL-33;Contains: RecName: Full=Interleukin-33(102-266);Contains: RecName: Full=Interleukin-33(109-266);Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 266 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il33	interleukin 33	86	103	2	44

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113336 Schmitz J, et al., IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005 Nov;23(5):479-90
J:152429 Talabot-Ayer D, et al., Interleukin-33 is biologically active independently of caspase-1 cleavage. J Biol Chem. 2009 Jul 17;284(29):19420-6
J:179171 Ali S, et al., The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription. J Immunol. 2011 Aug 15;187(4):1609-16
J:182032 Lefrancais E, et al., IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1673-8
J:274274 Osbourn M, et al., HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33. Immunity. 2017 Oct 17;47(4):739-751.e5
J:319416 Faas M, et al., IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity. 2021 Nov 9;54(11):2531-2546.e5
J:338168 Yamagishi R, et al., Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Sci Immunol. 2022 Jun 24;7(72):eabl7209
J:341429 Chen W, et al., Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion. Nat Immunol. 2022 Jul;23(7):1021-1030