Sequence Detail

ID/Version

Q8BVE8 B3VCH6 Q6ZPY1 Q811F0 Q7TSF5 (UniProt | EBI)

Last sequence update: 2006-10-31
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Histone-lysine N-methyltransferase NSD2; EC=2.1.1.357 {ECO:0000269|PubMed:19483677, ECO:0000269|PubMed:31636135, ECO:0000269|PubMed:32862441};AltName: Full=Multiple myeloma SET domain-containing protein; Short=MMSET;AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 1365 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nsd2	nuclear receptor binding SET domain protein 2	47	111	3	18

Sequence references in MGI

J:48436 Stec I, et al., WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma [published erratum appears in HumMol Genet 1998 Sep;7(9):1527]. Hum Mol Genet. 1998 Jul;7(7):1071-82
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150360 Nimura K, et al., A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature. 2009 Jul 9;460(7252):287-91
J:191725 Pei H, et al., The Histone Methyltransferase MMSET Regulates Class Switch Recombination. J Immunol. 2013 Jan 15;190(2):756-63
J:285064 Long X, et al., Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation. J Exp Med. 2020 Jan 6;217(1)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298767 Dobenecker MW, et al., The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice. FEBS Lett. 2020 Oct;594(20):3324-3337