Sequence Detail

ID/Version

Q8BUE1 Q3TCU9 Q9WUJ6 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Sodium/hydrogen exchanger 4;AltName: Full=Na(+)/H(+) exchanger 4; Short=NHE-4;AltName: Full=Solute carrier family 9 member 4;

Provider

SWISS-PROT

Sequence

Polypeptide 797 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc9a4	solute carrier family 9 (sodium/hydrogen exchanger), member 4	30	104	3	5

Sequence references in MGI

J:80600 Praetorius J, et al., NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2000 Feb;278(2):G197-206
J:98566 Gawenis LR, et al., Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger. J Biol Chem. 2005 Apr 1;280(13):12781-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:161635 Bourgeois S, et al., NHE4 is critical for the renal handling of ammonia in rodents. J Clin Invest. 2010 Jun 1;120(6):1895-904
J:321776 Sakuta H, et al., SLC9A4 in the organum vasculosum of the lamina terminalis is a [Na(+)] sensor for the control of water intake. Pflugers Arch. 2020 May;472(5):609-624