Sequence Detail

ID/Version

Q8BUD0 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=G-protein coupled receptor 4 {ECO:0000303|PubMed:17145776}; Short=mmGPR4 {ECO:0000303|PubMed:39753131};

Provider

SWISS-PROT

Sequence

Polypeptide 365 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gpr4	G protein-coupled receptor 4	47	97	3	22

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:118276 Yang LV, et al., Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Mol Cell Biol. 2007 Feb;27(4):1334-47
J:185906 Sun X, et al., Deletion of the pH sensor GPR4 decreases renal acid excretion. J Am Soc Nephrol. 2010 Oct;21(10):1745-55
J:224758 Kumar NN, et al., PHYSIOLOGY. Regulation of breathing by CO(2) requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. Science. 2015 Jun 12;348(6240):1255-60
J:283791 Wenzel J, et al., Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1753-1761
J:287083 Krewson EA, et al., The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells. iScience. 2020 Feb 21;23(2):100848
J:362019 Wen X, et al., Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4. Cell. 2024 Dec 31;