Sequence Detail

ID/Version

Q8BTM8 Q99KQ2 O54934 Q8VHX8 B7FAV0 Q8BTN7 Q8BLK1 Q7TQI1 Q8VHX5 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Filamin-A; Short=FLN-A;AltName: Full=Actin-binding protein 280; Short=ABP-280;AltName: Full=Alpha-filamin;AltName: Full=Endothelial actin-binding protein;AltName: Full=Filamin-1;AltName: Full=Non-muscle filamin;

Provider

SWISS-PROT

Sequence

Polypeptide 2647 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Flna	filamin, alpha	139	121	3	26

Sequence references in MGI

J:51716 Liu G, et al., Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol. 1997 Dec 29;139(7):1719-33
J:80557 van der Flier A, et al., Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol. 2002 Jan 21;156(2):361-76
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:118252 Feng Y, et al., Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19836-41
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:165730 Falet H, et al., A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010 Aug 30;207(9):1967-79
J:174390 Gay O, et al., RefilinB (FAM101B) targets FilaminA to organize perinuclear actin networks and regulates nuclear shape. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11464-9
J:181150 Adams M, et al., A meckelin-filamin A interaction mediates ciliogenesis. Hum Mol Genet. 2012 Mar 15;21(6):1272-86
J:201396 Sakane A, et al., Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins. Genes Cells. 2013 Sep;18(9):810-22
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:210363 Mizuhashi K, et al., Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Hum Mol Genet. 2014 Jun 1;23(11):2953-67
J:231247 Nakamura F, et al., Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling. Nat Commun. 2014;5:5325
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:349401 Proszynski TJ, et al., Amotl2 interacts with LL5beta, localizes to podosomes and regulates postsynaptic differentiation in muscle. J Cell Sci. 2013 May 15;126(Pt 10):2225-35