Sequence Detail

ID/Version

Q8BMT4 Q8BTT4 Q8BUI7 Q8BY16 Q8R063 Q3TIA8 (UniProt | EBI)

Last sequence update: 2005-10-25
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Transforming growth factor beta activator LRRC33 {ECO:0000305};AltName: Full=Leucine-rich repeat-containing protein 33 {ECO:0000305};AltName: Full=Negative regulator of reactive oxygen species {ECO:0000303|PubMed:24739962};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 693 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nrros	negative regulator of reactive oxygen species	22	98	3	10

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:209569 Noubade R, et al., NRROS negatively regulates reactive oxygen species during host defence and autoimmunity. Nature. 2014 May 8;509(7499):235-9
J:212032 Su X, et al., Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. J Leukoc Biol. 2014 Jul;96(1):17-26
J:257960 Wong K, et al., Mice deficient in NRROS show abnormal microglial development and neurological disorders. Nat Immunol. 2017 Jun;18(6):633-641
J:264027 Qin Y, et al., A Milieu Molecule for TGF-beta Required for Microglia Function in the Nervous System. Cell. 2018 Jun 28;174(1):156-171.e16