Sequence Detail

ID/Version

Q8BMP4 Q9D392 B2RRW0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=G-protein coupled estrogen receptor 1;AltName: Full=Chemoattractant receptor-like 2;AltName: Full=G protein-coupled estrogen receptor 1;AltName: Full=G-protein coupled receptor 30;AltName: Full=Membrane estrogen receptor; Short=mER;

Provider

SWISS-PROT

Sequence

Polypeptide 375 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gper1	G protein-coupled estrogen receptor 1	258	100	3	21

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131313 Wang C, et al., GPR30 Contributes to Estrogen-Induced Thymic Atrophy. Mol Endocrinol. 2008 Mar;22(3):636-48
J:145794 Otto C, et al., GPR30 does not mediate estrogenic responses in reproductive organs in mice. Biol Reprod. 2009 Jan;80(1):34-41
J:146345 Martensson UE, et al., Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology. 2009 Feb;150(2):687-98
J:163301 Haas E, et al., Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res. 2009 Feb 13;104(3):288-91
J:174852 Sharma G, et al., Mechanisms of Estradiol-Induced Insulin Secretion by the G Protein-Coupled Estrogen Receptor GPR30/GPER in Pancreatic {beta}-Cells. Endocrinology. 2011 Aug;152(8):3030-9
J:184133 Liu SB, et al., G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors. J Neurosci. 2012 Apr 4;32(14):4887-900
J:197102 Akama KT, et al., Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines. J Biol Chem. 2013 Mar 1;288(9):6438-50
J:200505 Sanden C, et al., G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments. Mol Pharmacol. 2011 Mar;79(3):400-10
J:201283 Ruiz-Palmero I, et al., G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17beta-estradiol in developing hippocampal neurons. Mol Cell Endocrinol. 2013 Jun 15;372(1-2):105-15
J:201441 Lenhart PM, et al., G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection. J Mol Endocrinol. 2013 Aug;51(1):191-202
J:201910 Zhu P, et al., GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion. Gen Comp Endocrinol. 2013 Nov 1;193:19-26
J:244903 Ford J, et al., GPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice. J Bone Miner Res. 2011 Feb;26(2):298-307