Sequence Detail

ID/Version

Q8BLN6 B8XCJ6 Q8BJN5 Q69Z93 B2KGG4 Q8BLP6 B2KGE8 (UniProt | EBI)

Last sequence update: 2022-02-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein unc-80 homolog; Short=mUNC-80;

Provider

SWISS-PROT

Sequence

Polypeptide 3326 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Unc80	unc-80, NALCN activator	15	96	2	7

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:145000 Lu B, et al., Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature. 2009 Feb 5;457(7230):741-4
J:167858 Lu B, et al., Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron. 2010 Nov 4;68(3):488-99
J:231930 Stray-Pedersen A, et al., Biallelic Mutations in UNC80 Cause Persistent Hypotonia, Encephalopathy, Growth Retardation, and Severe Intellectual Disability. Am J Hum Genet. 2016 Jan 7;98(1):202-9
J:291847 Wie J, et al., Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. Nat Commun. 2020 Jul 3;11(1):3351
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89