Sequence Detail

ID/Version

Q8BKJ9 Q6X7B7 A2ABY7 Q8QZZ5 (UniProt | EBI)

Last sequence update: 2003-10-31
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=NAD-dependent protein deacetylase sirtuin-7; EC=2.3.1.286 {ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:25200183, ECO:0000269|PubMed:31075303};AltName: Full=NAD-dependent protein deacylase sirtuin-7; EC=2.3.1.- {E

Provider

SWISS-PROT

Sequence

Polypeptide 402 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sirt7	sirtuin 7	80	105	3	13

Sequence references in MGI

J:108454 Ford E, et al., Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 2006 May 1;20(9):1075-80
J:147652 Vakhrusheva O, et al., Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res. 2008 Mar 28;102(6):703-10
J:234105 Vazquez BN, et al., SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair. EMBO J. 2016 Jul 15;35(14):1488-503
J:250978 Ianni A, et al., Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and Sirt1. Biochem Biophys Res Commun. 2017 Oct 21;492(3):434-440
J:256921 Fang J, et al., Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8352-E8361
J:266247 Fukuda M, et al., SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix. Nat Commun. 2018 Jul 19;9(1):2833
J:272987 Ryu D, et al., A SIRT7-dependent acetylation switch of GABPbeta1 controls mitochondrial function. Cell Metab. 2014 Nov 4;20(5):856-869
J:277821 Sobuz SU, et al., SIRT7 regulates the nuclear export of NF-kappaB p65 by deacetylating Ran. Biochim Biophys Acta Mol Cell Res. 2019 Sep;1866(9):1355-1367
J:281203 Vazquez BN, et al., SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina. Nucleic Acids Res. 2019 Sep 5;47(15):7870-7885
J:281207 Vazquez BN, et al., SIRT7 promotes chromosome synapsis during prophase I of female meiosis. Chromosoma. 2019 Sep;128(3):369-383