Sequence Detail

ID/Version

Q8BKH7 A2AN72 A2AR13 Q80UY4 A2AN74 Q8BMV5 Q8R2N9 A2AR16 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Target of rapamycin complex 2 subunit MAPKAP1 {ECO:0000305}; Short=TORC2 subunit MAPKAP1 {ECO:0000305};AltName: Full=Mitogen-activated protein kinase 2-associated protein 1 {ECO:0000303|PubMed:16962653};AltName: Full=Stress-activated

Provider

SWISS-PROT

Sequence

Polypeptide 522 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mapkap1	mitogen-activated protein kinase associated protein 1	21	98	3	25

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:125618 Jacinto E, et al., SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006 Oct 6;127(1):125-37
J:176618 Lu M, et al., mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel. J Biol Chem. 2011 Sep 2;286(35):30647-54
J:193606 Dai N, et al., mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts. Genes Dev. 2013 Feb 1;27(3):301-12
J:193983 Kim SJ, et al., mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol Cell. 2012 Dec 28;48(6):875-87
J:208097 Liu P, et al., Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013 Nov;15(11):1340-50
J:355636 Baffi TR, et al., mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Sci Signal. 2021 Apr 13;14(678)
J:355640 Humphrey SJ, et al., Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2. Cell Metab. 2013 Jun 4;17(6):1009-1020
J:355661 Yang G, et al., A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation. Cell Rep. 2015 Aug 11;12(6):937-43