Sequence Detail

ID/Version

Q8BHY3 Q99JK1 Q8BI26 Q6P5C6 (UniProt | EBI)

Last sequence update: 2007-05-29
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Anoctamin-1;AltName: Full=Transmembrane protein 16A;

Provider

SWISS-PROT

Sequence

Polypeptide 960 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ano1	anoctamin 1, calcium activated chloride channel	67	112	3	21

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:138613 Rock JR, et al., The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol. 2008 Sep 1;321(1):141-9
J:138798 Rock JR, et al., Expression of TMEM16 paralogs during murine embryogenesis. Dev Dyn. 2008 Sep;237(9):2566-74
J:141010 Yang YD, et al., TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature. 2008 Oct 30;455(7217):1210-5
J:165954 Schreiber R, et al., Expression and function of epithelial anoctamins. J Biol Chem. 2010 Mar 5;285(10):7838-45
J:188263 Yang H, et al., TMEM16F Forms a Ca(2+)-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation. Cell. 2012 Sep 28;151(1):111-22
J:190271 Duran C, et al., ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C482-93
J:191353 Cho H, et al., The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci. 2012 Jul;15(7):1015-21
J:212044 Takayama Y, et al., Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. FASEB J. 2014 May;28(5):2238-48
J:255382 Benedetto R, et al., Epithelial Chloride Transport by CFTR Requires TMEM16A. Sci Rep. 2017 Sep 29;7(1):12397
J:276378 Paulino C, et al., Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A. Elife. 2017 May 31;6:e26232
J:276557 Hong GS, et al., ANO1/TMEM16A regulates process maturation in radial glial cells in the developing brain. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12494-12499
J:278999 Qu M, et al., Smooth muscle cell-specific deletion does not alter Ca2+ signaling, uterine contraction, gestation length, or litter size in mice. Biol Reprod. 2019 Aug 1;101(2):318-327
J:287874 Benedetto R, et al., TMEM16A is indispensable for basal mucus secretion in airways and intestine. FASEB J. 2019 Mar;33(3):4502-4512
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:295452 Amjad A, et al., Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol. 2015 Apr;145(4):285-301
J:297325 Dang S, et al., Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 Dec 21;552(7685):426-429
J:297326 Paulino C, et al., Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM. Nature. 2017 Dec 21;552(7685):421-425
J:322930 Hernandez-Clavijo A, et al., TMEM16A and TMEM16B Modulate Pheromone-Evoked Action Potential Firing in Mouse Vomeronasal Sensory Neurons. eNeuro. 2021 Sep-Oct;8(5):ENEURO.0179-21.2021
J:322946 Maul A, et al., The Cl(-)-channel TMEM16A is involved in the generation of cochlear Ca(2+) waves and promotes the refinement of auditory brainstem networks in mice. Elife. 2022 Feb 7;11:e72251
J:326502 Jeon JH, et al., Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. PLoS One. 2013;8(6):e67989