Sequence Detail

ID/Version

Q8BGW1 Q6ZPI7 Q3TTZ5 Q8BR68 Q9QZ13 Q8CB66 Q8R250 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Alpha-ketoglutarate-dependent dioxygenase FTO {ECO:0000305};AltName: Full=Fat mass and obesity-associated protein {ECO:0000303|PubMed:17991826};AltName: Full=Protein fatso {ECO:0000303|PubMed:10501967};AltName: Full=U6 small nuclear RNA (2'-

Provider

SWISS-PROT

Sequence

Polypeptide 502 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fto	FTO alpha-ketoglutarate dependent dioxygenase	77	112	3	63

Sequence references in MGI

J:57790 Peters T, et al., Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome. 1999 Oct;10(10):983-6
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:141150 Jia G, et al., Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett. 2008 Oct 15;582(23-24):3313-9
J:147471 Fischer J, et al., Inactivation of the Fto gene protects from obesity. Nature. 2009 Apr 16;458(7240):894-8
J:152163 Church C, et al., A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet. 2009 Aug;5(8):e1000599
J:157439 Gerken T, et al., The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 2007 Nov 30;318(5855):1469-72
J:166829 Church C, et al., Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet. 2010 Dec;42(12):1086-92
J:194922 McMurray F, et al., Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet. 2013 Jan;9(1):e1003166
J:203742 Hess ME, et al., The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci. 2013 Aug;16(8):1042-8
J:208887 Smemo S, et al., Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014 Mar 20;507(7492):371-5
J:215262 Stratigopoulos G, et al., Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab. 2014 May 6;19(5):767-79
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89