Sequence Detail

ID/Version

Q8BGW0 Q3TEM0 Q3UU76 Q8BGP0 Q8C9S6 Q059Y0 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein THEMIS;AltName: Full=Grb2-associating protein; Short=Gasp;AltName: Full=Protein thylex;AltName: Full=Thymocyte-expressed molecule involved in selection;

Provider

SWISS-PROT

Sequence

Polypeptide 636 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Themis	thymocyte selection associated	23	97	3	25

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:151074 Fu G, et al., Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol. 2009 Aug;10(8):848-56
J:151075 Lesourne R, et al., Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol. 2009 Aug;10(8):840-7
J:151076 Johnson AL, et al., Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol. 2009 Aug;10(8):831-9
J:152601 Kakugawa K, et al., A novel gene essential for the development of single positive thymocytes. Mol Cell Biol. 2009 Sep;29(18):5128-35
J:153235 Patrick MS, et al., Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16345-50
J:186446 Wang D, et al., Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol. 2012 Jun;13(6):560-8