Sequence Detail

ID/Version

Q8BGD7 Q3V3U3 (UniProt | EBI)

Last sequence update: 2003-03-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Neuronal PAS domain-containing protein 4 {ECO:0000305}; Short=Neuronal PAS4 {ECO:0000305};AltName: Full=HLH-PAS transcription factor NXF {ECO:0000303|PubMed:14701734};AltName: Full=Limbic-enhanced PAS protein {ECO:0000303|PubMed:1536

Provider

SWISS-PROT

Sequence

Polypeptide 802 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Npas4	neuronal PAS domain protein 4	53	106	4	12

Sequence references in MGI

J:80366 Ooe N, et al., Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Mol Cell Biol. 2004 Jan;24(2):608-16
J:93202 Moser M, et al., LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element. Brain Res Mol Brain Res. 2004 Sep 28;128(2):141-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143367 Lin Y, et al., Activity-dependent regulation of inhibitory synapse development by Npas4. Nature. 2008 Oct 30;455(7217):1198-204
J:145569 Ooe N, et al., Functional characterization of basic helix-loop-helix-PAS type transcription factor NXF in vivo: putative involvement in an 'on demand' neuroprotection system. J Biol Chem. 2009 Jan 9;284(2):1057-63
J:179046 Ramamoorthi K, et al., Npas4 regulates a transcriptional program in CA3 required for contextual memory formation. Science. 2011 Dec 23;334(6063):1669-75
J:192118 Coutellier L, et al., Npas4: a neuronal transcription factor with a key role in social and cognitive functions relevant to developmental disorders. PLoS One. 2012;7(9):e46604
J:207770 Bloodgood BL, et al., The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature. 2013 Nov 7;503(7474):121-5
J:210031 Bersten DC, et al., Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs. Biochim Biophys Acta. 2014 Jan;1839(1):13-24
J:214381 Spiegel I, et al., Npas4 regulates excitatory-inhibitory balance within neural circuits through cell-type-specific gene programs. Cell. 2014 May 22;157(5):1216-29
J:223967 Jaehne EJ, et al., Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour. Behav Brain Res. 2015 Mar 15;281:276-82
J:234547 Ye L, et al., Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences. Cell. 2016 Jun 16;165(7):1776-88
J:238807 Wu D, et al., NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. Elife. 2016 Oct 26;5:e18790
J:244786 Coutellier L, et al., Npas4 deficiency increases vulnerability to juvenile stress in mice. Behav Brain Res. 2015 Dec 15;295:17-25