Sequence Detail

ID/Version

Q811U4 Q99M10 Q811D5 Q3URC4 Q9D395 Q8CEY6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Mitofusin-1; EC=3.6.5.- {ECO:0000250|UniProtKB:Q8IWA4};AltName: Full=Transmembrane GTPase MFN1;

Provider

SWISS-PROT

Sequence

Polypeptide 741 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mfn1	mitofusin 1	39	102	3	16

Sequence references in MGI

J:81438 Chen H, et al., Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol. 2003 Jan 21;160(2):189-200
J:92425 Koshiba T, et al., Structural basis of mitochondrial tethering by mitofusin complexes. Science. 2004 Aug 6;305(5685):858-62
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:198571 Chen Y, et al., PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science. 2013 Apr 26;340(6131):471-5
J:211366 Yue W, et al., A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res. 2014 Apr;24(4):482-96
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89