Sequence Detail

ID/Version

Q811T9 Q8CHP1 Q7TQ21 Q8CF88 Q8CHP2 Q8CF87 (UniProt | EBI)

Last sequence update: 2006-06-13
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Disrupted in schizophrenia 1 homolog {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 852 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Disc1	disrupted in schizophrenia 1	122	119	3	19

Sequence references in MGI

J:80804 Ma L, et al., Cloning and Characterization of Disc1, the Mouse Ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 2002 Dec;80(6):662-72
J:81177 Ozeki Y, et al., Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):289-94
J:82003 Taylor MS, et al., Evolutionary constraints on the Disrupted in Schizophrenia locus. Genomics. 2003 Jan;81(1):67-77
J:147568 Mao Y, et al., Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009 Mar 20;136(6):1017-31
J:151421 Meyer KD, et al., Disc1 regulates granule cell migration in the developing hippocampus. Hum Mol Genet. 2009 Sep 1;18(17):3286-97
J:154919 Kim JY, et al., DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. 2009 Sep 24;63(6):761-73
J:159140 Duan X, et al., Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. 2007 Sep 21;130(6):1146-58
J:167582 Fukuda T, et al., CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J Biol Chem. 2010 Dec 24;285(52):40554-61
J:177836 Carlisle HJ, et al., Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction. J Neurosci. 2011 Nov 9;31(45):16194-207